
Alice had likely been influenced by Alicia's innate sense of compassion. Rather than arrest her, Alice offered to help Lisa expose Umbrella's bio-weapons research through a plan to disable the Red Queen security system and allow the theft of a T-virus sample. In 2002, Alice began talking to an Umbrella researcher named Lisa Addison, who was secretly a mole working for former FBI agent Matt Addison. They became romantically involved at some point down the line. To the public, she was married to Spence however, their marriage was a sham for the sake of guarding the mansion. Alice's purpose was to protect the Looking Glass House and she remained unaware of her true nature as a clone, thinking that she was the original as all Umbrella clones were created to believe.

Infected after escaping the Undead-infested facility, Alice was taken away by Umbrella for testing.

Both Alice and Spence were knocked unconscious when the security system released noxious gas and were rendered amnesiac. This plan ultimately failed when her co-worker, Spence stole the virus samples with the intention of getting rich on the black market and leaked the virus into the lab to kill the research staff in the confusion. Originally a high-ranking Umbrella security operator, she joined a deep cover operation by members of the US law enforcement to reveal the company's illegal viral research data to the world. Isaacs after regaining her memoriesĪlice was a leading party in the conflict against the Umbrella Corporation during the Global T-virus Pandemic.
